ALBA Lab
Structural and Functional Biology of Tumor Metabolism
Most relevant publications on the subject, as of February 2024
A full list of publications, including collaborative work, can be foun in this link to Google Scholar.
Published Online: October 19, 2023; Issue Date: December, 2023
Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection.
Douglas Adamoski, Marilia M Dias, Jose Edwin N Quesñay, Zhengyi Yang, Ievgeniia Zagoriy, Anna M Steyer, Camila T Rodrigues, Alliny CS Bastos, Bianca N Silva, Renna KE Costa, Flávia MO Abreu, Zeyaul Islam, Alexandre Cassago, Marin G van Heel, Sílvio R Consonni, Simone Mattei, Julia Mahamid, Rodrigo V Portugal, Andre LB Ambrosio*, and Sandra MG Dias*. *Corresponding authors
Nature Structural & Molecular Biology 30, 1902-1912 DOI: 10.1038/s41594-023-01118-0
Published Online: March 18, 2021; Issue Date: June, 2021
Structure and activation mechanism of the human liver-type glutaminase GLS2.
Igor M Ferreira, José Edwin N Quesñay, Alliny CS Bastos, Camila T Rodrigues, Melanie Vollmar, Tobias Krojer, Claire Strain-Damerell, Nicola A Burgess-Brown, Frank von Delft, Wyatt W Yue*, Sandra MG Dias*, and Andre LB Ambrosio*. *Corresponding authors
Biochimie 185, 96-104 DOI: 10.1016/j.biochi.2021.03.009
Published: November 19, 2020
Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier.
José Edwin N Quesñay, Naomi L Pollock, Raghavendra SK Nagampalli, Sarah C Lee, Vijayakumar Balakrishnan, Sandra MG Dias, Isabel Moraes, Tim R Dafforn, and Andre LB Ambrosio*. *Corresponding author
Biology 9(11), 407 DOI: 10.3390/biology9110407
Published Online: September 20, 2019; Issue Date: January 16, 2020
GLS2 is protumorigenic in breast cancers.
Marilia M Dias, Douglas Adamoski, Larissa M Dos Reis, Carolline FR Ascenção, Krishina RS de Oliveira, Ana Carolina Paschoalini Mafra, Alliny Cristiny da Silva Bastos, Melissa Quintero, Carolina de G Cassago, Igor M Ferreira, Carlos HV Fidelis, Silvana A Rocco, Marcio Chaim Bajgelman, Zachary Stine, Ioana Berindan-Neagoe, George A Calin, Andre LB Ambrosio*, and Sandra MG Dias*. *Corresponding authors
Oncogene 39, 690-702 DOI: 10.1038/s41388-019-1007-z
Publication: October 8, 2018
Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ (PPARγ) via Direct Interaction.
Carolina AG Cassago, Marília M Dias, Matheus P Pinheiro, Camila C Pasquali, Alliny CS Bastos, Zeyaul Islam, Sílvio R Consonni, Juliana F Oliveira, Emerson M Gomes, Carolline FR Ascenção, Rodrigo V Honorato, Bianca A Pauletti, Nathalia C Indolfo, Helder VR Filho, Paulo SL de Oliveira, Ana Carolina M Figueira, Adriana F Paes Leme, Andre LB Ambrosio*, and Sandra MG Dias*. *Corresponding authors
Biochemistry 57 (44), 6293-6307 DOI: 10.1021/acs.biochem.8b00773
Publication: February 22, 2018
Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter.
Raghavendra SK Nagampalli, José Edwin N Quesñay, Douglas Adamoski, Zeyaul Islam, James Birch, Heitor G Sebinelli, Richard MBM Girard, Carolline FR Ascenção, Angela M Fala, Bianca A Pauletti, Sílvio R Consonni, Juliana F Oliveira, Amanda CT Silva, Kleber G Franchini, Adriana F Paes Leme, Ariel M Silber, Pietro Ciancaglini, Isabel Moraes, Sandra MG Dias*, and Andre LB Ambrosio*. *Corresponding authors
Scientific Reports 8, 3510 DOI: 10.1038/s41598-018-21740-z
Publication: July 17, 2017
The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.
Camila C Pasquali, Zeyaul Islam, Douglas Adamoski, Igor M Ferreira, Ricardo D Righetto, Jefferson Bettini, Rodrigo V Portugal, Wyatt W Yue, Ana Gonzalez, Sandra MG Dias*, and Andre LB Ambrosio*. *Corresponding authors
Journal of Biological Chemistry 292 (27), 11572-11585 DOI: 10.1074/jbc.M117.787291
Published Online: February 4, 2016; Issue Date: February 18, 2016
Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.
Roxana S Redis, Luz E Vela, Weiqin Lu, Juliana F de Oliveira, Cristina Ivan, Cristian Rodriguez-Aguayo, Douglas Adamoski, Barbara Pasculli, Ayumu Taguchi, Yunyun Chen, Agustin F Fernandez, Luis Valledor, Katrien Van Roosbroeck, Samuel Chang, Maitri Shah, Garrett Kinnebrew, Leng Han, Yaser Atlasi, Lawrence H Cheung, Gilbert Y Huang, Paloma Monroig, Marc S Ramirez, Tina Catela Ivkovic, Long Van, Hui Ling, Roberta Gafà, Sanja Kapitanovic, Giovanni Lanza, James A Bankson, Peng Huang, Stephen Y Lai, Robert C Bast, Michael G Rosenblum, Milan Radovich, Mircea Ivan, Geoffrey Bartholomeusz, Han Liang, Mario F Fraga, William R Widger, Samir Hanash, Ioana Berindan-Neagoe, Gabriel Lopez-Berestein, Andre LB Ambrosio, Sandra M Gomes Dias, George A Calin.
Molecular Cell 61 (4), 520-534 DOI: 10.1016/j.molcel.2016.01.015
Publication date: August 3, 2015
Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.
Angela M Fala, Juliana F Oliveira, Douglas Adamoski, Juliana A Aricetti, Marilia M Dias, Marcio VB Dias, Maurício L Sforça, Paulo S Lopes-de-Oliveira, Silvana A Rocco, Camila Caldana, Sandra MG Dias*, and Andre LB Ambrosio*. *Corresponding authors
Scientific Reports 5, 12698 DOI: 10.1038/srep12698
Publication date: September 27, 2013
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor.
Amanda PS Ferreira, Alexandre Cassago, Kaliandra A Goncalves, Marília M Dias, Douglas Adamoski, Carolline FR Ascenção, Rodrigo V Honorato, Juliana F de Oliveira, Igor M Ferreira, Camila Fornezari, Jefferson Bettini, Paulo Sérgio L Oliveira, Adriana F Paes Leme, Rodrigo V Portugal, Andre LB Ambrosio*, and Sandra MG Dias*. *Corresponding authors
Journal of Biological Chemistry 288 (39), 28009-28020 DOI: 10.1074/jbc.M113.501346
Publication date: January 6, 2012
Mitochondrial Localization and Structure-based Phosphate Activation Mechanism of Glutaminase C with Implications for Cancer Metabolism.
Alexandre Cassago, Amanda PS Ferreira, Igor M Ferreira, Camila Fornezari, Emerson RM Gomes, Kai Su Greene, Humberto M Pereira, Richard C Garratt, Sandra MG Dias*, Andre LB Ambrosio*. *Corresponding authors
PNAS 109 (4), 1092-1097 DOI: 10.1073/pnas.1112495109
Publication date: September 14, 2010
Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation.
Jian-Bin Wang, Jon W Erickson, Reina Fuji, Sekar Ramachandran, Ping Gao, Ramani Dinavahi, Kristin F Wilson, Andre LB Ambrosio, Sandra MG Dias, Chi V Dang, and Richard A Cerione
Cancer cell 18 (3), 207-219 DOI: 10.1016/j.ccr.2010.08.009
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