Amanda Eiriz Feu, Jean Paulo de Andrade, Alejandro Pedro Ayala, Larissa Costa de Almeida, Leticia V. Costa-Lotufo, Jaume Bastida, Javier Ellena, Warley de Souza Borges,
The present work focused on the chemical study of the main alkaloid component in Brazilian indigenous Amaryllidaceae species Hippeastrum puniceum (Lam.) Kuntze. The strategy applied was based on a distinct partitioning process and chromatographic-purification steps using the crude methanolic extract as the starting material. In this way, the glycosylated derivative narciclasine-4-O-β-D-xylopyranoside was isolated from the ethyl acetate fraction of H. puniceum. Structural elucidation of the compound was performed through NMR (Nuclear Magnetic Resonance) analysis including mono- and bi-dimensional experiments. The absolute configuration was determined herein for the first time by means of X-Ray Crystallography. The compound was also evaluated as cytotoxic agent against colon (HCT 116) and breast (MCF-7) tumor cells, showing no significant activity at the tested concentrations of 10 and 50 μM.
https://doi.org/10.1016/j.sajb.2020.09.006
@article{Feu_2021, doi = {10.1016/j.sajb.2020.09.006}, url = {https://doi.org/10.1016%2Fj.sajb.2020.09.006}, year = 2021, month = {jan}, publisher = {Elsevier {BV}}, volume = {136}, pages = {30--34}, author = {Amanda Eiriz Feu and Jean Paulo de Andrade and Alejandro Pedro Ayala and Larissa Costa de Almeida and Leticia V. Costa-Lotufo and Jaume Bastida and Javier Ellena and Warley de Souza Borges}, title = {Glycosylated narciclasine alkaloid in Hippeastrum puniceum (Lam.) Kuntze}, journal = {South African Journal of Botany} }