Marília I. F. Barbosa, Rodrigo S. Corrêa, Adriana P. M. Guedes, Alex M. Graça, Francyelli M. Andrade, Celisnólia M. Leite, Elisângela P. Silveira-Lacerda, Javier Ellena, Henrique V. Reis, Antônio C. Doriguetto, Alzir A. Batista,
Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6, where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.
https://doi.org/10.3390/inorganics11070270
@article{Barbosa_2023, doi = {10.3390/inorganics11070270}, url = {https://doi.org/10.3390%2Finorganics11070270}, year = 2023, month = {jun}, publisher = {{MDPI} {AG}}, volume = {11}, number = {7}, pages = {270}, author = {Mar{\'{\i}}lia I. F. Barbosa and Rodrigo S. Corr{\^{e}}a and Adriana P. M. Guedes and Alex M. Gra{\c{c}}a and Francyelli M. Andrade and Celisn{\'{o}}lia M. Leite and Elis{\^{a}}ngela P. Silveira-Lacerda and Javier Ellena and Henrique V. Reis and Ant{\^{o}}nio C. Doriguetto and Alzir A. Batista}, title = {Nitrosyl/Diphenylphosphine/Amino Acid{\textendash}Ruthenium Complexes as Inhibitors of {MDA}-{MB}-231 Breast Cancer Cells}, journal = {Inorganics} }